Divergent Pathways of Gentrification

Two Cheers for Gentrification

Dishevelled: at the crossroads of divergent intracellular signaling pathways

During the development of multicellular organisms the formation of complex patterns relies on specific cell-cell signaling events. For tissues to become spatially organized and cells to become committed to specialized fates it is absolutely crucial for proper development that the underlying signaling systems receive and route information correctly. Recently, a wealth of genetic and biochemical ...

Divergent pathways in the biosynthesis of bisindole natural products.

Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the "bisindoles." Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarified the biosynthetic construction of six bisindole molecules, revealing novel enzymatic mechanisms...

Divergent pathways of programming: prenatal vs. postnatal protein undernutrition.

AS FIRST PROPOSED BY David Barker (2) and now supported by numerous epidemiological and experimental studies (1, 12, 21), fetal undernutrition leads to permanent structural and physiological alterations resulting in the development of hypertension and cardiovascular disease. Although epidemiological studies provide the basis for investigation into mechanisms linking birth weight and adult disea...

Kinetic origin of divergent decompression pathways in silicon and germanium.

Silicon and germanium transform from diamond to β-tin structure under compression, but upon decompression they turn into metastable BC8 Si and ST12 Ge phases, respectively, instead of returning to the lowest-enthalpy diamond structure. Here we explore by first-principles calculations the atomistic mechanism underlying this intriguing phenomenon. We identify a body-centered tetragonal structure ...